Organoids

Organoids are cell-based 3D models of different human organs. They can bring new insights into human development and disease that cannot be unravel with 2D cell cultures and animal models.

Organoids recapitulate the complexity of human organs with high-fidelity and can be used as preclinical models for several applications, including disease modelling, drug screening, biomarker discovery and prediction of patient-specific response to therapy.

Zenit Science offers

  • Organoid models derived from human stem cells originated from healthy donor tissues or patients carrying disease-associated gene mutations.
  • Uniform organoids that are reliable and reproducible, mimicking responses in humans
  • More predictable results than animal models and cell cultures.
  • A technological platform that reduces/replaces the use of animal models.
  • Preclinical data often required for FDA approval to subsequent clinical studies.

Human organoids key features

Human organoids hold incredible promise for the future of medicine, offering hope for new treatments, insights into disease mechanisms, and personalized approaches to healthcare.
  • Clinically relevant models: Many biological processes are specific to the human body and cannot be modelled in other animals, such as brain development, metabolism, and drug response. Traditional 2D (monolayer) cell cultures lack the complexity of human tissue. The organoid technology The organoid technology enables high-fidelity prediction of biological outcomes in the human setting, promoting translation from basic science into clinical practice.
  • Patient-derived 3D models: Unique biological models generated from skin biopsies of patients carrying disease-associated mutations. Ideal models for applications envisioning personalized medicine.​
  • Scalability: Adaptable for large-scale screens. The amplification and cryopreservation of organoids enables high throughput analyses.
  • Practical: Organoids can be maintained for over one year, enabling studies of long-term treatment effect or toxicity.
  • Ethics: Sustainable and ethical alternative to traditional animal models.
  • Cost-benefit: Organoids are adaptable and cost-effective compared to traditional approaches. To achieve your goals and maximize results, we provide a comprehensive suite of assays, ranging from drug toxicity assessments and 3D imaging to single cell technologies.

Our services include:

Next-generation drug discovery and development

Test efficacy, safety, pharmacokinetic properties and elucidate mechanism of action of candidate drugs.

Safety and toxicity studies

Evaluate safety and toxicity profiles of drugs and drug combinations using organoids derived from healthy non-transformed cells.

Disease modeling

Recapitulate disease progression and reveal new mechanistic insight into disease pathology.

Biomarker discovery

Identify and validate candidate biomarkers to monitor disease progression, predict and evaluate therapeutic response.

Personalized medicine

Identify targeted and personalized therapies and stratify your patient population

Reliable quality control and reporting

Zenit Sciences implement rigorous quality control measures to ensure accurate and reliable results. The quality of the 3D models is verified via morphological assessments using imaging analysis, and identification of cell type content within organoids is  validated via qPCR and IHC using cell markers. Data from our organoid-based assay services are acquired utilizing state-of-the-art technologies to ensure high specificity, accuracy and reproducibility of measurements performed with low sample quantity. We provide a comprehensive and detailed report of each test, customized to your requirements

To learn more about our services and discuss possible collaboration please contact us using the formular below

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